Structure of PDB 5b4u Chain A

Receptor sequence
>5b4uA (length=260) Species: 511 (Alcaligenes faecalis) [Search protein sequence]
MLKGKKAVVTGSTSGIGLAMATELAKAGADVVINGFGQPEDIERERSTLE
SKFGVKAYYLNADLSDAQATRDFIAKAAEALGGLDILVNNAGIQHTAPIE
EFPVDKWNAIIALNLSAVFHGTAAALPIMQKQGWGRIINIASAHGLVASV
NKSAYVAAKHGVVGLTKVTALENAGKGITCNAICPGWVRTPLVEKQIEAI
SQQKGIDIEAAARELLAEKQPSLQFVTPEQLGGAAVFLSSAAADQMTGTT
LSLDGGWTAR
3D structure
PDB5b4u Structural insights into the catalytic reaction trigger and inhibition of D-3-hydroxybutyrate dehydrogenase
ChainA
Resolution1.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G15 N114 S142 Y155 K159 I200
Catalytic site (residue number reindexed from 1) G15 N114 S142 Y155 K159 I200
Enzyme Commision number 1.1.1.30: 3-hydroxybutyrate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A G11 T13 S14 G15 I16 F36 A62 D63 L64 N90 A91 G92 L113 I140 S142 Y155 K159 P185 G186 W187 V188 T190 L192 V193 G11 T13 S14 G15 I16 F36 A62 D63 L64 N90 A91 G92 L113 I140 S142 Y155 K159 P185 G186 W187 V188 T190 L192 V193
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003858 3-hydroxybutyrate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5b4u, PDBe:5b4u, PDBj:5b4u
PDBsum5b4u
PubMed27380367
UniProtD0VWQ0

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