Structure of PDB 5b4t Chain A

Receptor sequence
>5b4tA (length=260) Species: 511 (Alcaligenes faecalis) [Search protein sequence]
MLKGKKAVVTGSTSGIGLAMATELAKAGADVVINGFGQPEDIERERSTLE
SKFGVKAYYLNADLSDAQATRDFIAKAAEALGGLDILVNNAGIQHTAPIE
EFPVDKWNAIIALNLSAVFHGTAAALPIMQKQGWGRIINIASAHGLVASV
NKSAYVAAKHGVVGLTKVTALENAGKGITCNAICPGWVRTPLVEKQIEAI
SQQKGIDIEAAARELLAEKQPSLQFVTPEQLGGAAVFLSSAAADQMTGTT
LSLDGGWTAR
3D structure
PDB5b4t Structural insights into the catalytic reaction trigger and inhibition of D-3-hydroxybutyrate dehydrogenase
ChainA
Resolution1.19 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G15 N114 S142 Y155 K159 I200
Catalytic site (residue number reindexed from 1) G15 N114 S142 Y155 K159 I200
Enzyme Commision number 1.1.1.30: 3-hydroxybutyrate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A G11 T13 G15 I16 F36 D63 L64 N90 G92 L113 I140 Y155 K159 P185 G186 W187 V188 T190 L192 V193 G11 T13 G15 I16 F36 D63 L64 N90 G92 L113 I140 Y155 K159 P185 G186 W187 V188 T190 L192 V193
BS02 3HR A Q94 S142 H144 K152 Y155 W187 Q196 Q94 S142 H144 K152 Y155 W187 Q196
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003858 3-hydroxybutyrate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5b4t, PDBe:5b4t, PDBj:5b4t
PDBsum5b4t
PubMed27380367
UniProtD0VWQ0

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