Structure of PDB 5b3a Chain A

Receptor sequence

>5b3aA (length=382) Species: 272557 (Aeropyrum pernix K1)

ALADISGYLDVLDSVRGFSYLENAREVLRSGEARCLGNPRSEPEYVKALY
VIGASRIPVGDGCSHTLEELGVFDISVPGEMVFPSPLDFFERGKPTPLVR
SRLQLPNGVRVWLKLEWYNPFSLSVKDRPAVEIISRLSRRVEKGSLVADA
TSSNFGVALSAVARLYGYRARVYLPGAAEEFGKLLPRLLGAQVIVDPEAP
STVHLLPRVMKDSKNEGFVHVNQFYNDANFEAHMRGTAREIFVQSRRGGL
ALRGVAGSLGTSGHMSAAAFYLQSVDPSIRAVLVQPAQGDSIPGIRRVET
GMLWINMLDISYTLAEVTLEEAMEAVVEVARSDGLVIGPSGGAAVKALAK
KAAEGDLEPGDYVVVVPDTGFKYLSLVQNALE

3D structure

• PDB: 5b3a Role of F225 in O-phosphoserine sulfhydrylase from Aeropyrum pernix K1
• Chain: A
• Resolution: 2.14 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K127 S341
• Catalytic site (residue number reindexed from 1): K126 S340
• Enzyme Commision number: 2.5.1.47: cysteine synthase.
  2.5.1.65: O-phosphoserine sulfhydrylase.
  4.2.1.22: cystathionine beta-synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	0JO	A	K127 T152 S153 N155 F156 G261 T262 S263 G264 H265 G295 I296 S341 P368	K126 T151 S152 N154 F155 G260 T261 S262 G263 H264 G294 I295 S340 P367

Gene Ontology

Molecular Function

• GO:0004122 cystathionine beta-synthase activity
• GO:0004124 cysteine synthase activity
• GO:0016740 transferase activity
• GO:0016829 lyase activity
• GO:0033847 O-phosphoserine sulfhydrylase activity

Biological Process

• GO:0006534 cysteine metabolic process
• GO:0006535 cysteine biosynthetic process from serine
• GO:0009069 serine family amino acid metabolic process
• GO:0019344 cysteine biosynthetic process
• GO:0044272 sulfur compound biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5b3a, PDBe:5b3a, PDBj:5b3a
• PDBsum: 5b3a
• PubMed: 27377295
• UniProt: Q9YBL2|CYSO_AERPE Protein CysO (Gene Name=cysO)