Structure of PDB 5b36 Chain A

Receptor sequence

>5b36A (length=382) Species: 272557 (Aeropyrum pernix K1)

ALADISGYLDVLDSVRGFSYLENAREVLRSGEARCLGNPRSEPEYVKALY
VIGASRIPVGDGCSHTLEELGVFDISVPGEMVFPSPLDFFERGKPTPLVR
SRLQLPNGVRVWLKLEWYNPFSLSVKDRPAVEIISRLSRRVEKGSLVADA
TSSNFGVALSAVARLYGYRARVYLPGAAEEFGKLLPRLLGAQVIVDPEAP
STVHLLPRVMKDSKNEGFVHVNQFYNDANFEAHMRGTAREIFVQSRRGGL
ALRGVAGSLGTSGHMSAAAFYLQSVDPSIRAVLVQPAQGDSIPGIRRVET
GMLWINMLDISYTLAEVTLEEAMEAVVEVARSDGLVIGPSGGAAVKALAK
KAAEGDLEPGDYVVVVPDTGFKYLSLVQNALE

3D structure

• PDB: 5b36 Role of F225 in O-phosphoserine sulfhydrylase from Aeropyrum pernix K1
• Chain: A
• Resolution: 2.15 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K127 S341
• Catalytic site (residue number reindexed from 1): K126 S340
• Enzyme Commision number: 2.5.1.47: cysteine synthase.
  2.5.1.65: O-phosphoserine sulfhydrylase.
  4.2.1.22: cystathionine beta-synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PLP	A	K127 N155 G261 T262 S263 H265 G295 I296 S341 P368	K126 N154 G260 T261 S262 H264 G294 I295 S340 P367
BS02	CYS	A	K127 T152 S153 N155 F156 F225 G261 G295	K126 T151 S152 N154 F155 F224 G260 G294

Gene Ontology

Molecular Function

• GO:0004122 cystathionine beta-synthase activity
• GO:0004124 cysteine synthase activity
• GO:0016740 transferase activity
• GO:0016829 lyase activity
• GO:0033847 O-phosphoserine sulfhydrylase activity

Biological Process

• GO:0006534 cysteine metabolic process
• GO:0006535 cysteine biosynthetic process from serine
• GO:0009069 serine family amino acid metabolic process
• GO:0019344 cysteine biosynthetic process
• GO:0044272 sulfur compound biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5b36, PDBe:5b36, PDBj:5b36
• PDBsum: 5b36
• PubMed: 27377295
• UniProt: Q9YBL2|CYSO_AERPE Protein CysO (Gene Name=cysO)