Structure of PDB 5axa Chain A

Receptor sequence
>5axaA (length=429) Species: 10090 (Mus musculus) [Search protein sequence]
KLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGC
LHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWK
GETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKYPQLLSGIRGI
SEETTTGVHNLYKMMSNGILKVPAINVNDSVTKSKFDNLYGCRESLIDGI
KRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAA
MEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFD
VEIDVKWLNENAVEKVNIKPQVDRYWLKNGRRIILLAEGRLVNLGCAMGH
PSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLN
VKLTKLTEKQAQYLGMPINGPFKPDHYRY
3D structure
PDB5axa Crystal structure of mouse SAHH complexed with adenosine
ChainA
Resolution1.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H55 S78 S83 D131 E156 N181 K186 D190 N191 C195 H301 H353 S361 Q365
Catalytic site (residue number reindexed from 1) H52 S75 S80 D128 E153 N178 K183 D187 N188 C192 H298 H350 S358 Q362
Enzyme Commision number 3.13.2.1: adenosylhomocysteinase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0004013 adenosylhomocysteinase activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0051287 NAD binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0019510 S-adenosylhomocysteine catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0042470 melanosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5axa, PDBe:5axa, PDBj:5axa
PDBsum5axa
PubMed
UniProtP50247|SAHH_MOUSE Adenosylhomocysteinase (Gene Name=Ahcy)

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