Structure of PDB 5awj Chain A

Receptor sequence
>5awjA (length=240) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMSPLSMLPHLADLV
SYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDM
SWDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLM
AICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMI
QKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGN
3D structure
PDB5awj Fine tuning of agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I238 K242 I256 K260 P412 E416 I58 K62 I76 K80 P232 E236
BS02 YSL A Y143 S233 R270 S271 S274 W282 C284 H393 Y21 S53 R90 S91 S94 W102 C104 H213 MOAD: ic50=0.21nM
PDBbind-CN: -logKd/Ki=9.68,IC50=0.21nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5awj, PDBe:5awj, PDBj:5awj
PDBsum5awj
PubMed26515040
UniProtP13053|VDR_RAT Vitamin D3 receptor (Gene Name=Vdr)

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