Structure of PDB 5awc Chain A

Receptor sequence
>5awcA (length=749) Species: 9606 (Homo sapiens) [Search protein sequence]
SRSYPCDEKKQVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESF
QGLQNLTKINLNHNPNVGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLP
ESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDG
VFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGL
INLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLS
STSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLS
FNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPN
LSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLDFEFDPHSNFYH
FTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQ
VLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFR
IAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNR
LDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTEL
HINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLL
SHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLEL
HGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLE
3D structure
PDB5awc Structure-based Design of Human TLR8-specific Agonists with Augmented Potency and Adjuvanticity
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 M4D A D543 D545 T574 D474 D476 T505 BindingDB: EC50=27nM
BS02 M4D A Y348 Y353 V378 F405 Y303 Y308 V333 F360 BindingDB: EC50=27nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5awc, PDBe:5awc, PDBj:5awc
PDBsum5awc
PubMed26351878
UniProtQ9NR97|TLR8_HUMAN Toll-like receptor 8 (Gene Name=TLR8)

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