Structure of PDB 5avi Chain A

Receptor sequence
>5aviA (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
PQLSPEQLGMIEKLVAAQQRVTPWPPHSREARQQRFAHFTELAIVSVQEI
VDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKD
FSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSAD
RPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLS
SVHSEQVFALRLQDKKLPPLLSEIWDVH
3D structure
PDB5avi Discovery and structure-guided optimization of tert-butyl 6-(phenoxymethyl)-3-(trifluoromethyl)benzoates as liver X receptor agonists
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Q266 V269 K273 R283 E284 I287 K291 P437 E441 Q48 V51 K55 R65 E66 I69 K73 P219 E223
BS02 4KM A F257 L260 A261 S264 M298 E301 T302 R305 F315 F335 F39 L42 A43 S46 M80 E83 T84 R87 F97 F117 PDBbind-CN: -logKd/Ki=6.06,Ki=0.87uM
BindingDB: EC50=310nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5avi, PDBe:5avi, PDBj:5avi
PDBsum5avi
PubMed26238323
UniProtQ13133|NR1H3_HUMAN Oxysterols receptor LXR-alpha (Gene Name=NR1H3)

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