Structure of PDB 5aqw Chain A

Receptor sequence
>5aqwA (length=379) Species: 9606 (Homo sapiens) [Search protein sequence]
KAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIG
DAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPK
VQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFND
SQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTERNVLIFDLGGGTF
DVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQ
NKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEEL
CSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFN
GRDLNKSINPDEAVAYGAAVQAAILIKST
3D structure
PDB5aqw A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
ChainA
Resolution1.53 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D10 K71 E175 D199
Catalytic site (residue number reindexed from 1) D8 K69 E173 D194
Enzyme Commision number 3.6.3.51: Transferred entry: 7.4.2.3.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5P7 A G202 E268 K271 R272 S275 G339 R342 G197 E263 K266 R267 S270 G334 R337
BS02 PO4 A T14 Y15 G201 G202 T12 Y13 G196 G197
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0140662 ATP-dependent protein folding chaperone

View graph for
Molecular Function
External links
PDB RCSB:5aqw, PDBe:5aqw, PDBj:5aqw
PDBsum5aqw
PubMed27708405
UniProtP0DMV8|HS71A_HUMAN Heat shock 70 kDa protein 1A (Gene Name=HSPA1A)

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