Structure of PDB 5ao4 Chain A

Receptor sequence
>5ao4A (length=430) Species: 9606 (Homo sapiens) [Search protein sequence]
MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNR
FEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFS
HMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED
ICFIKEQIVGPLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHH
LGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRR
AYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKL
TDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKRED
YESLPKEVASAKPKVLLDVKLKAEDFIVDVINMHVSFYCKTAPEQLIRVY
CKKVDRKSLYAARQYFVQWCADRNFTKPQD
3D structure
PDB5ao4 Phospho-Dependent Regulation of Samhd1 Oligomerisation Couples Catalysis and Restriction.
ChainA
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A H167 D207 D311 H53 D93 D189
BS02 GTP A K116 D137 R145 F165 K2 D23 R31 F51
BS03 GTP A Y155 V156 R451 Y41 V42 R329
External links
PDB RCSB:5ao4, PDBe:5ao4, PDBj:5ao4
PDBsum5ao4
PubMed26431200
UniProtQ9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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