Structure of PDB 5ao3 Chain A

Receptor sequence
>5ao3A (length=440) Species: 9606 (Homo sapiens) [Search protein sequence]
MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNR
FEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFS
HMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED
ICFIKEQIVGPLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHH
LGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRR
AYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKL
TDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKRED
YESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYNPIDHVSFYCKTAPN
RAIEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQD
3D structure
PDB5ao3 Phospho-Dependent Regulation of Samhd1 Oligomerisation Couples Catalysis and Restriction.
ChainA
Resolution3.004 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A H167 H206 D207 D311 H53 H92 D93 D189
BS02 GTP A K116 V117 I118 D137 R145 K2 V3 I4 D23 R31
BS03 GTP A Y155 V156 V378 R451 Y41 V42 V256 R329
External links
PDB RCSB:5ao3, PDBe:5ao3, PDBj:5ao3
PDBsum5ao3
PubMed26431200
UniProtQ9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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