Structure of PDB 5ao0 Chain A

Receptor sequence
>5ao0A (length=439) Species: 9606 (Homo sapiens) [Search protein sequence]
IHVDTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPG
ASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLG
HGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGL
IPEEDICFIKEQIVGPLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFA
RDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRN
SLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDME
AYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIK
IKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMHVSFYCKTAPNR
AIREQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQ
3D structure
PDB5ao0 Phospho-Dependent Regulation of Samhd1 Oligomerisation Couples Catalysis and Restriction.
ChainA
Resolution3.731 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A H167 H206 D207 D311 H58 H97 D98 D194
BS02 DG3 A R164 H206 D207 H215 H233 D311 K312 Y315 Y374 R55 H97 D98 H106 H124 D194 K195 Y198 Y257
BS03 DG3 A K116 I118 D137 R145 K7 I9 D28 R36
BS04 DG3 A Y155 V156 V378 R451 Y46 V47 V261 R334
External links
PDB RCSB:5ao0, PDBe:5ao0, PDBj:5ao0
PDBsum5ao0
PubMed26431200
UniProtQ9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

[Back to BioLiP]