Structure of PDB 5ahf Chain A

Receptor sequence
>5ahfA (length=229) Species: 28901 (Salmonella enterica) [Search protein sequence]
MIIPALNLIDGTVVRLQRDYGNDPLPRLQDYAAQGAGVLHLVDLTGAKDP
AKRQIPLIKTLVAGVNVPVQVGGGVRTEEDVAALLKAGVARVVIGSTAVK
SPDVVKGWFERFGAQALVLALDVRIDEHGTKQVAVSGWQENSGVSLEQLV
ETYLPVGLKHVLCTDISNVSLYEEVCARYPQIAFQSSGGIGDIDDIAALR
GTGVRGVIVGRALLEGKFTVKEAIQCWQN
3D structure
PDB5ahf Two-Step Ligand Binding in a Beta/Alpha8 Barrel Enzyme -Substrate-Bound Structures Shed New Light on the Catalytic Cycle of Hisa
ChainA
Resolution2.201 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N7 D129
Catalytic site (residue number reindexed from 1) N7 D122
Enzyme Commision number 5.3.1.16: 1-(5-phosphoribosyl)-5- [(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GUO A N7 R15 L51 G81 G102 S103 A127 S202 G225 R226 N7 R15 L44 G74 G95 S96 A120 S187 G210 R211
Gene Ontology
Molecular Function
GO:0003949 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity
GO:0016853 isomerase activity
Biological Process
GO:0000105 L-histidine biosynthetic process
GO:0000162 tryptophan biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ahf, PDBe:5ahf, PDBj:5ahf
PDBsum5ahf
PubMed26294764
UniProtP10372|HIS4_SALTY 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (Gene Name=hisA)

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