Structure of PDB 5ah2 Chain A

Receptor sequence
>5ah2A (length=380) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
TDLKFRVVREDFADAVAWVARSLPTRPTIPVLAGVLLTGTDEGLTISGFD
YEVSAEVKVSAEIASAGSVLVSGRLLSDITKALPAKPVEVSVEGTRVSLT
CGSARFSLPTLAVEDYPALPALPEETGVIASDLFAEAIGQVAVAAGRLPM
LTGIRVEISGESVVLAATDRFRLAVRELTWVTTAGDVEAAVLVPAKTLAE
AAKAGTDGNQVHLALGSGASVGKDGLLGIRSEGKRSTTRLLDAEFPKFRQ
LLPAEHTAVATIGVAELTEAIKRVALVADRGAQIRMEFSDDTLKLSAGAD
DVGRAEEDLPVDFAGEPLTIAFNPTYLTDGLGSLHSERVTFGFTTPSRPA
VLRPAGEGGSGPFPAAKTDYVYLLMPVRLP
3D structure
PDB5ah2 Antibiotics. Targeting Dnan for Tuberculosis Therapy Using Novel Griselimycins.
ChainA
Resolution2.129 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R181 F182 L262 M391 P392 V393 R394 R170 F171 L251 M375 P376 V377 R378
BS02 peptide A I37 Y59 D123 R250 I29 Y51 D115 R239
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0046677 response to antibiotic
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0009360 DNA polymerase III complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5ah2, PDBe:5ah2, PDBj:5ah2
PDBsum5ah2
PubMed26045430
UniProtA0QND6|DPO3B_MYCS2 Beta sliding clamp (Gene Name=dnaN)

[Back to BioLiP]