Structure of PDB 5ags Chain A

Receptor sequence
>5agsA (length=192) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
GAVALFSARAVDIEVFTTRPDTLFGATYLVLAPEHDLVDELVAASWPAGV
NPLWTYGGGTPGEAIAAYRRAIAAKSDLERQEEKTGVFLGSYAINPANGE
PVPIFIADYVLAGYGTGAIMAVPGHDQRDWDFARAFGLPIVEVIAGGNIS
ESAYTGDGILVNSDYLNGMSVPAAKRAIVDRLESAGRGRARI
3D structure
PDB5ags Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
ChainA
Resolution1.47 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.4: leucine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 38Y A F335 T336 T337 R338 T341 V431 L432 Y435 I440 M441 V443 H446 D447 R449 D450 F16 T17 T18 R19 T22 V110 L111 Y114 I119 M120 V122 H125 D126 R128 D129 PDBbind-CN: -logKd/Ki=7.40,Kd=0.040uM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0004823 leucine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006429 leucyl-tRNA aminoacylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5ags, PDBe:5ags, PDBj:5ags
PDBsum5ags
PubMed27503647
UniProtP9WFV1|SYL_MYCTU Leucine--tRNA ligase (Gene Name=leuS)

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