Structure of PDB 5afg Chain A

Receptor sequence
>5afgA (length=83) Species: 9606 (Homo sapiens) [Search protein sequence]
TLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDAAQQHIV
YCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLV
3D structure
PDB5afg Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K51 L54 L57 G58 I61 M62 Y67 Q72 H73 V93 H96 K26 L29 L32 G33 I36 M37 Y42 Q47 H48 V68 H71
BS02 P07 A F55 M62 F30 M37
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:5afg, PDBe:5afg, PDBj:5afg
PDBsum5afg
PubMed26768531
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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