Structure of PDB 5aer Chain A

Receptor sequence

>5aerA (length=181) Species: 10116 (Rattus norvegicus) [Search protein sequence]

PEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFG
DPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYD
LDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKN
ADGKLTLQEFQEGSKADPSIVQALSLYDGLV

3D structure

PDB

5aer Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-Protein-Coupled Receptor Kinase 1 (Grk1) Peptides Using Different Modes of Interactions.

Chain

Resolution

2.19 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	W30 G33 F34 D37 I51 Y52 Q54 F55 F64 L183 S184	W21 G24 F25 D28 I42 Y43 Q45 F46 F55 L174 S175
BS02	peptide	A	F55 F56 Y129 M131 V132 G133 V136 L138 E142 Q181 A182 Y186	F46 F47 Y120 M122 V123 G124 V127 L129 E133 Q172 A173 Y177
BS03	CA	A	D73 N75 D77 R79 E81 E84	D64 N66 D68 R70 E72 E75
BS04	CA	A	D109 D111 D113 Y115 E120	D100 D102 D104 Y106 E111
BS05	CA	A	D157 N159 D161 K163 E168	D148 N150 D152 K154 E159

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0005245	voltage-gated calcium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008048	calcium sensitive guanylate cyclase activator activity
GO:0008427	calcium-dependent protein kinase inhibitor activity
GO:0019901	protein kinase binding
GO:0046872	metal ion binding

	Biological Process
GO:0010975	regulation of neuron projection development
GO:0045921	positive regulation of exocytosis
GO:0050850	positive regulation of calcium-mediated signaling
GO:0070588	calcium ion transmembrane transport
GO:0099509	regulation of presynaptic cytosolic calcium ion concentration
GO:2000300	regulation of synaptic vesicle exocytosis

	Cellular Component
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0030424	axon
GO:0030425	dendrite
GO:0031045	dense core granule
GO:0044305	calyx of Held
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm
GO:0098794	postsynapse
GO:0098978	glutamatergic synapse
GO:0099523	presynaptic cytosol
GO:0099524	postsynaptic cytosol

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5aer, PDBe:5aer, PDBj:5aer
PDBsum	5aer
PubMed	25979333
UniProt	P62168\|NCS1_RAT Neuronal calcium sensor 1 (Gene Name=Ncs1)

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