Structure of PDB 5aeh Chain A

Receptor sequence
>5aehA (length=208) Species: 9606 (Homo sapiens) [Search protein sequence]
GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVC
NKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYI
GGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRV
TLGKSFLQFSKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLI
TYQIMRPE
3D structure
PDB5aeh Development and Structural Analysis of Adenosine Site Binding Tankyrase Inhibitors.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8IR A S1033 F1035 A1038 G1043 D1045 H1048 Y1060 Y1071 I1075 S82 F84 A87 G92 D94 H97 Y109 Y120 I124 MOAD: ic50=0.037uM
PDBbind-CN: -logKd/Ki=7.43,IC50=0.037uM
BindingDB: IC50=37nM
BS02 ZN A C1081 H1084 C1089 C1092 C130 H133 C138 C141
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5aeh, PDBe:5aeh, PDBj:5aeh
PDBsum5aeh
PubMed26706174
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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