Structure of PDB 5ae9 Chain A

Receptor sequence
>5ae9A (length=858) Species: 10090 (Mus musculus) [Search protein sequence]
RVKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQL
GWVEWLQYSFPLQLEPSARGNRALLVNVKFEGSEESFTFQVSTKDMPLAL
MACALRKKATVFRQPLVEQPEEYALQVNGRHEYLYGNYPLCHFQYICSCL
HSGLTPHLTMVHSSSILAMRDEQSNSLWSLEQPFSIELIEGRKVNADERM
KLVVQAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLEFDISVCDLPRMAR
LCFALYAVVDCPIAWANLMLFDYKDQLKTGERCLYMWPSVLLNPAGTVRG
NPNTESAAALVIYLPEVAPHPVYFPALEKILELGRHGERGRITEEEQLQL
REILERELYEHEKDLVWKMRHEVQEHFPEALARLLLVTKWNKHEDVAQML
YLLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQL
VQVLKYESYLDCELTKFLLGRALANRKIGHFLFWHLRSEMHVPSVALRFG
LIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKTTKPQTKEMM
HMCMRQETYMEALSHLQSPLDPSTLLEEVCVEQCTFMDSKMKPLWIMYSS
EEAGSAGNVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGC
LPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPG
EALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHF
LGNERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLF
LHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALR
ESWKTKVN
3D structure
PDB5ae9 Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase Gamma for the Treatment of Respiratory Disease.
ChainA
Resolution2.44 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.137: phosphatidylinositol 3-kinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OKO A M752 S754 W760 I777 K779 D787 I825 V827 V828 D832 M900 I910 D911 M587 S589 W595 I612 K614 D622 I660 V662 V663 D667 M735 I745 D746 MOAD: Ki=0.0794nM
Gene Ontology
Molecular Function
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
Biological Process
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0046854 phosphatidylinositol phosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5ae9, PDBe:5ae9, PDBj:5ae9
PDBsum5ae9
PubMed26301626
UniProtO35904|PK3CD_MOUSE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Gene Name=Pik3cd)

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