Structure of PDB 5ad2 Chain A

Receptor sequence
>5ad2A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB5ad2 Potent and Selective Bivalent Inhibitors of Bet Bromodomains
ChainA
Resolution2.01 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ETU A W81 F83 Y139 D145 I146 M149 W40 F42 Y98 D104 I105 M108 MOAD: Kd=63nM
BindingDB: Ki=316nM,IC50=25nM
External links
PDB RCSB:5ad2, PDBe:5ad2, PDBj:5ad2
PDBsum5ad2
PubMed27775716
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

[Back to BioLiP]