Structure of PDB 5acy Chain A

Receptor sequence
>5acyA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB5acy Autism-Like Syndrome is Induced by Pharmacological Suppression of Bet Proteins in Young Mice.
ChainA
Resolution2.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9S3 A W81 P82 L92 Y139 I146 W40 P41 L51 Y98 I105 MOAD: Kd=6.4nM
PDBbind-CN: -logKd/Ki=8.19,Kd=6.4nM
BindingDB: IC50=398nM
External links
PDB RCSB:5acy, PDBe:5acy, PDBj:5acy
PDBsum5acy
PubMed26392221
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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