Structure of PDB 5acn Chain A

Receptor sequence
>5acnA (length=754) Species: 9823 (Sus scrofa) [Search protein sequence]
QRAKVAMSHFEPHEYIRYDLLEKNIDIVRKRLNRPLTLSEKIVYGHLDDP
ANQEIERGKTYLRLRPDRVAMQDATAQMAMLQFISSGLPKVAVPSTIHCD
HLIEAQLGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWRPGSGIIHQII
LENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCP
KVIGVKLTGSLSGWTSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISC
TGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRADIANLADEFKDHLV
PDPGCHYDQVIEINLSELKPHINGPFTPDLAHPVAEVGSVAEKEGWPLDI
RVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATI
ERDGYAQVLRDVGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFT
GRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDFLTGKDGKKFKLEAP
DADELPRAEFDPGQDTYQHPPKDSSGQRVDVSPTSQRLQLLEPFDKWDGK
DLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENR
KANSVRNAVTQEFGPVPDTARYYKQHGIRWVVIGDENYGEGSSREHSALE
PRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQ
GLKDFAPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKE
LQQK
3D structure
PDB5acn Structure of activated aconitase: formation of the [4Fe-4S] cluster in the crystal.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D100 H101 D165 R447 S642 R644
Catalytic site (residue number reindexed from 1) D100 H101 D165 R447 S642 R644
Enzyme Commision number 4.2.1.3: aconitate hydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F3S A I145 H147 H167 C358 C421 C424 N446 I145 H147 H167 C358 C421 C424 N446
BS02 TRC A K198 G235 R666 K198 G235 R666
Gene Ontology
Molecular Function
GO:0003994 aconitate hydratase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006099 tricarboxylic acid cycle
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5acn, PDBe:5acn, PDBj:5acn
PDBsum5acn
PubMed2726740
UniProtP16276|ACON_PIG Aconitate hydratase, mitochondrial (Gene Name=ACO2)

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