Structure of PDB 5a8e Chain A

Receptor sequence
>5a8eA (length=285) Species: 9103 (Meleagris gallopavo) [Search protein sequence]
LSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLAC
ADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASVWTLCVI
AIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDE
DPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAK
EQIRKRKTSRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDL
VPDWLFVAFNWLGYANSAMNPIILCRSPDFRKAFK
3D structure
PDB5a8e Pharmacological Analysis and Structure Determination of 7-Methylcyanopindolol-Bound Beta1-Adrenergic Receptor.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XTK A W117 D121 V122 Y207 A208 S211 S215 F306 F307 N310 N329 Y333 W82 D86 V87 Y172 A173 S176 S180 F237 F238 N241 N260 Y264 MOAD: Kd=0.042nM
BS02 MHA A G110 S111 P196 G75 S76 P161
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004935 adrenergic receptor activity
GO:0004940 beta1-adrenergic receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0045823 positive regulation of heart contraction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5a8e, PDBe:5a8e, PDBj:5a8e
PDBsum5a8e
PubMed26385885
UniProtP07700|ADRB1_MELGA Beta-1 adrenergic receptor (Gene Name=ADRB1)

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