Structure of PDB 5a83 Chain A

Receptor sequence
>5a83A (length=130) Species: 9606 (Homo sapiens) [Search protein sequence]
SMQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYVTVIKQP
MDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRA
CALRDTAYAIIKEELDEDFEQLCEEIQESR
3D structure
PDB5a83 Structure-Based Optimization of Naphthyridones Into Potent Atad2 Bromodomain Inhibitors.
ChainA
Resolution2.09 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YD3 A V1008 V1013 D1014 E1017 V1018 N1064 G1070 D1071 I1074 R1077 V30 V35 D36 E39 V40 N86 G92 D93 I96 R99 MOAD: ic50=0.158uM
PDBbind-CN: -logKd/Ki=6.80,IC50=0.158uM
BindingDB: IC50=158nM,Kd=60nM
External links
PDB RCSB:5a83, PDBe:5a83, PDBj:5a83
PDBsum5a83
PubMed26230603
UniProtQ6PL18|ATAD2_HUMAN ATPase family AAA domain-containing protein 2 (Gene Name=ATAD2)

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