Structure of PDB 5a82 Chain A

Receptor sequence
>5a82A (length=130) Species: 9606 (Homo sapiens) [Search protein sequence]
SMQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYVTVIKQP
MDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRA
CALRDTAYAIIKEELDEDFEQLCEEIQESR
3D structure
PDB5a82 Structure-Based Optimization of Naphthyridones Into Potent Atad2 Bromodomain Inhibitors.
ChainA
Resolution1.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YEJ A V1008 V1013 N1064 G1070 D1071 I1074 R1077 V30 V35 N86 G92 D93 I96 R99 MOAD: ic50=2.51uM
PDBbind-CN: -logKd/Ki=5.60,IC50=2.51uM
BindingDB: Kd=1100nM,IC50=2512nM
External links
PDB RCSB:5a82, PDBe:5a82, PDBj:5a82
PDBsum5a82
PubMed26230603
UniProtQ6PL18|ATAD2_HUMAN ATPase family AAA domain-containing protein 2 (Gene Name=ATAD2)

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