Structure of PDB 5a6n Chain A

Receptor sequence
>5a6nA (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
MVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVS
REEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAE
KESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRI
KLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVIT
YILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLV
KDPKRRMTIAQSLEHSWIKAI
3D structure
PDB5a6n De Novo Fragment Design for Drug Discovery and Chemical Biology.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D139 K141 E143 N144 D161 T180
Catalytic site (residue number reindexed from 1) D132 K134 E136 N137 D154 T173
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U7E A K42 D161 K35 D154 MOAD: ic50=52uM
PDBbind-CN: -logKd/Ki=4.28,IC50=52uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5a6n, PDBe:5a6n, PDBj:5a6n
PDBsum5a6n
PubMed26486226
UniProtO43293|DAPK3_HUMAN Death-associated protein kinase 3 (Gene Name=DAPK3)

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