Structure of PDB 5a69 Chain A

Receptor sequence
>5a69A (length=585) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence]
RFTGLSLKQTQAIEVLKHISLPVEVAVTQSDQASISIEGEEGHYQLTYRK
PHQLYRALSLLVTVLADKVEIEEQAAYEDLAYMVDCSRNAVLNVASAKQM
IEILALMGYSTFELYMEDTYQIEGQPYFGYFRGAYSAEELQEIEAYAQQF
DVTFVPCIQTLAHLSAFVKWGVKEVQELRDVEDILLIGEEKVYDLIDGMF
ATLSKLKTRKVNIGMDEAHLVGLGRYLILNRLLMCQHLERVLDIADKYGF
HCQMWSDMFDRVTLVYWDYYQDSEEKYNRNFRNHHKIDLAFAGGAWKWIG
FTPHNHFSRLVAIEANKACRANQIKEVIVTGWGDNGGETAQFSILPSLQI
WAELSYRNDLDGLSAHFKTNTGLTVEDFMQIDLANLLPDLPGNLSGINPN
RYVFYQDILCPILDQHMTPEQDKPHFAQAAETLANIKEKAGNYAYLFETQ
AQLNAILSSKVDVGRRIRQAYQADDKESLQQIARQELPELRSQIEDFHAL
FSHQWLKENKVFGLDTVDIRMGGLLQRIKRAESRIEVYLAGQLDRIDELE
VEILPFTDFYADKDFAATTANQWHTIATASTIYTT
3D structure
PDB5a69 A Second beta-Hexosaminidase Encoded in the Streptococcus pneumoniae Genome Provides an Expanded Biochemical Ability to Degrade Host Glycans.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OGN A R94 D222 E223 W266 W306 Y308 Y309 W339 W373 D375 R88 D216 E217 W255 W267 Y269 Y270 W298 W332 D334 MOAD: Ki=1.1nM
PDBbind-CN: -logKd/Ki=8.96,Ki=1.1nM
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004563 beta-N-acetylhexosaminidase activity
GO:0015929 hexosaminidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5a69, PDBe:5a69, PDBj:5a69
PDBsum5a69
PubMed26491009
UniProtA0A0H2US73

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