Structure of PDB 5a5s Chain A

Receptor sequence
>5a5sA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHKFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB5a5s Fragment-Based Discovery of Low-Micromolar Atad2 Bromodomain Inhibitors.
ChainA
Resolution1.36 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NP8 A W81 P82 L92 N140 I146 W40 P41 L51 N99 I105 MOAD: ic50=1.3uM
PDBbind-CN: -logKd/Ki=5.90,IC50=1.26uM
BindingDB: IC50=15849nM
External links
PDB RCSB:5a5s, PDBe:5a5s, PDBj:5a5s
PDBsum5a5s
PubMed26155854
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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