Structure of PDB 5a5r Chain A

Receptor sequence
>5a5rA (length=130) Species: 9606 (Homo sapiens) [Search protein sequence]
SMQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYVTVIKQP
MDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRA
CALRDTAYAIIKEELDEDFEQLCEEIQESR
3D structure
PDB5a5r Fragment-Based Discovery of Low-Micromolar Atad2 Bromodomain Inhibitors.
ChainA
Resolution2.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NP8 A V1013 E1017 V1018 N1064 D1071 I1074 V35 E39 V40 N86 D93 I96 MOAD: ic50=1.3uM
PDBbind-CN: -logKd/Ki=5.90,IC50=1.26uM
BindingDB: IC50=3981nM
External links
PDB RCSB:5a5r, PDBe:5a5r, PDBj:5a5r
PDBsum5a5r
PubMed26155854
UniProtQ6PL18|ATAD2_HUMAN ATPase family AAA domain-containing protein 2 (Gene Name=ATAD2)

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