Structure of PDB 5a5p Chain A

Receptor sequence
>5a5pA (length=130) Species: 9606 (Homo sapiens) [Search protein sequence]
SMQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYVTVIKQP
MDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRA
CALRDTAYAIIKEELDEDFEQLCEEIQESR
3D structure
PDB5a5p Fragment-Based Discovery of Low-Micromolar Atad2 Bromodomain Inhibitors.
ChainA
Resolution2.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JTF A V1008 V1013 V1018 Y1063 N1064 D1071 I1074 V30 V35 V40 Y85 N86 D93 I96 MOAD: ic50=0.1mM
PDBbind-CN: -logKd/Ki=4.00,IC50=100uM
BindingDB: IC50=100000nM
External links
PDB RCSB:5a5p, PDBe:5a5p, PDBj:5a5p
PDBsum5a5p
PubMed26155854
UniProtQ6PL18|ATAD2_HUMAN ATPase family AAA domain-containing protein 2 (Gene Name=ATAD2)

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