Structure of PDB 5a5o Chain A

Receptor sequence
>5a5oA (length=130) Species: 9606 (Homo sapiens) [Search protein sequence]
SMQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYVTVIKQP
MDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRA
CALRDTAYAIIKEELDEDFEQLCEEIQESR
3D structure
PDB5a5o Fragment-Based Discovery of Low-Micromolar Atad2 Bromodomain Inhibitors.
ChainA
Resolution2.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J5I A V1008 V1018 N1064 I1074 V30 V40 N86 I96 PDBbind-CN: -logKd/Ki=3.00,IC50>1mM
BindingDB: IC50=<1000000nM
External links
PDB RCSB:5a5o, PDBe:5a5o, PDBj:5a5o
PDBsum5a5o
PubMed26155854
UniProtQ6PL18|ATAD2_HUMAN ATPase family AAA domain-containing protein 2 (Gene Name=ATAD2)

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