Structure of PDB 5a5l Chain A

Receptor sequence

>5a5lA (length=338) Species: 146786 (Thermosynechococcus vestitus)

SMDNVIGLEIIEVVEQAAIASARWMGKGDKNMADQAAVDAMRNRMNQIHM
RGRIVIGEGERDEAPMLYIGEEVGICTRPDAAQYCNPEELIEIDIAVDPC
EGTNLCAYGQPGSMAVLAISEKGGLFAAPDFYMKKLAAPPAAKGKVDIRN
SATENLKILSECLDRAIDELVVVVMKRDRHNDLIQEIRDAGARVQLISDG
DVSAALACAFSGTNIHALMGIGAAPEGVISAAAMRALGGHFQGQLVYDPA
VVMTKEWANRTREGNLEELKKAGITDPDKVYEAEELASGETVLFAACGIT
PGMLMKGVRFFKGGARTQSLVISTQSKTARFVDTIHMF

3D structure

• PDB: 5a5l Structure of the Dual-Function Fructose-1,6/Sedoheptulose-1, 7-Bisphosphatase from Thermosynechococcus Elongatus Bound with Sedoheptulose-7-Phosphate.
• Chain: A
• Resolution: 2.34 Å

Enzymatic activity

• Enzyme Commision number: 3.1.3.11: fructose-bisphosphatase.
  3.1.3.37: sedoheptulose-bisphosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	VTB	A	E100 Y131 M174 R176 R178 D198 G199 D200 G221 A222	E101 Y132 M175 R177 R179 D199 G200 D201 G222 A223
BS02	MG	A	D33 E57	D34 E58
BS03	MG	A	D97 E225	D98 E226

Gene Ontology

Molecular Function

• GO:0016787 hydrolase activity
• GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
• GO:0046872 metal ion binding
• GO:0050278 sedoheptulose-bisphosphatase activity

Biological Process

• GO:0006071 glycerol metabolic process
• GO:0006094 gluconeogenesis
• GO:0019253 reductive pentose-phosphate cycle
• GO:0030388 fructose 1,6-bisphosphate metabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:5a5l, PDBe:5a5l, PDBj:5a5l
• PDBsum: 5a5l
• PubMed: 26457528
• UniProt: Q8DJE9|FBSB_THEVB D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase (Gene Name=tll1276)