Structure of PDB 5a3u Chain A

Receptor sequence
>5a3uA (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]
QTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTD
KITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYP
GNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFA
DIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYL
TGEKGVRVELNKPSD
3D structure
PDB5a3u Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H313 D315 H374 H109 D111 H170
BS02 R8J A Y303 H313 D315 R322 R383 W389 Y99 H109 D111 R118 R179 W185 PDBbind-CN: -logKd/Ki=8.32,IC50=4.8nM
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:5a3u, PDBe:5a3u, PDBj:5a3u
PDBsum5a3u
PubMed26147748
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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