Structure of PDB 5a22 Chain A

Receptor sequence
>5a22A (length=2002) Species: 11276 (Vesicular stomatitis virus) [Search protein sequence]
NHADYNLNSPLISDDIDNLIRKFNSLPIPSMWDSKNWDGVLEMLTSCQAN
PISTSQMHKWMGSWLMSDNHDASQGYSFLHEVDKEAEITFDVVETFIRGW
GNKPIEYIKKERWTDSFKILAYLCQKFLDLHKLTLILNAVSEVELLNLAR
TFKGKVRRSSHGTNICRIRVPSLGPTFISEGWAYFKKLDILMDRNFLLMV
KDVIIGRMQTVLSMVCRIDNLFSEQDIFSLLNIYRIGDKIVERQGNFSYD
LIKMVEPICNLKLMKLARESRPLVPQFPHFENHIKTSVDEGAKIDRGIRF
LHDQIMSVKTVDLTLVIYGSFRHWGHPFIDYYTGLEKLHSQVTMKKDIDV
SYAKALASDLARIVLFQQFNDHKKWFVNGDLLPHDHPFKSHVKENTWPTA
AQVQDFGDKWHELPLIKCFEIPDLLDPSIIYSDKSHSMNRSEVLKHVRMN
PNTPIPSKKVLQTMLDTKATNWKEFLKEIDEKGLDDDDLIIGLKGKEREL
KLAGRFFSLMSWKLREYFVITEYLIKTHFVPMFKGLTMADDLTAVIKKML
DSSSGQGLKSYEAICIANHIDYEKWNNHQRKLSNGPVFRVMGQFLGYPSL
IERTHEFFEKSLIYYNGRPDLMRVHNNTLINSTSQRVCWQGQEGGLEGLR
QKGWTILNLLVIQREAKIRNTAVKVLAQGDNQVICTQYKTKKSRNVVELQ
GALNQMVSNNEKIMTAIKIGTGKLGLLINDDETMQSADYLNYGKIPIFRG
VIRGLETKRWSRVTCVTNDQIPTCANIMSSVSTNALTVAHFAENPINAMI
QYNYFGTFARLLLMMHDPALRQSLYEVQDKIPGLHSSTFKYAMLYLDPSI
GGVSGMSLSRFLIRAFPDPVTESLSFWRFIHVHARSEHLKEMSAVFGNPE
IAKFRITHIDKLVEDPTSLNIAMGMSPANLLKTEVKKCLIESRQTIRNQV
IKDATIYLYHEEDRLRSFLWSINPLFPRFLSEFKSGTFLGVADGLISLFQ
NSRTIRNSFKKKYHRELDDLIVRSEVSSLTHLGKLHLRRGSCKMWTCSAT
HADTLRYKSWGRTVIGTTVPHPLEMLGPQHRKETPCAPCNTSGFNYVSVH
CPDGIHDVFSSRGPLPAYLGSKTSESTSILQPWERESKVPLIKRATRLRD
AISWFVEPDSKLAMTILSNIHSLTGEEWTKRQHGFKRTGSALHRFSTSRM
SHGGFASQSTAALTRLMATTDTMRDLGDQNFDFLFQATLLYAQITTTVAR
DGWITSCTDHYHIACKSCLRPIEEITLDSSMDYTPPDVSHVLKTWRNGEG
QSYQVGRCIGFLYGDLAYRKSTHAEDSSLFPLSIQGRIRGRGFLKGLLDG
LMRASCCQVIHRRSLAHLKRPANAVYGGLIYLIDKLSVSPPFLSLTRSGP
IRDELETIPHKIPTSYPTSNRDMGVIVRNYFKYQCRLIEKGKYRSHYSQL
WLFSDVLSIDFIGPFSISTTLLQILYKPFLSGKDKNELRELANLSSLLRS
YPPWGRESRGTITTIPVYYTTTPYPKMLEMPPRIQNPLLSGIRLGQLPTG
AHYKIRSILHGMGIHYRDFLSCGDGSGGMTAALLRENVHSRGIFNSLLEL
SGSVMRGASPEPPSALETLGGDKSRCVNGETCWEYPSDLCDPRTWDYFLR
LKAGLGLQIDLIVMDMEVRDSSTSLKIETNVRNYVHRILDEQGVLIYKTY
GTYICESEKNAVTILGPMFKTVDLVQTEFSSSQTSEVYMVCKPDWSSINE
SWKNLYAFQSSEQEFARAKKVSTYFTLTGIPSQFIPDPFVNIETMLQIFG
VPTGVSHAAALKSSDRPADLLTISLFYMAIISYYNINHIRVGPIPPNPPS
DGIAQNVGIAITGISFWLSLMEKDIPLYQQCLAVIQQSFPIRWEAVSVKG
GYKQKWSTRGDGLPKDTRISDSLAPIGNWIRSLELVRNQVRLNPFNEILF
NQLCRTVDNHLKWSNLRRNTGMIEWINRRISKEDRSILMLKSDLHEENSW
RD
3D structure
PDB5a22 Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy.
ChainA
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.375: NNS virus cap methyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.88: GDP polyribonucleotidyltransferase.
3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1081 E1108 C1299 C1302 C1047 E1074 C1265 C1268
BS02 ZN A H1294 H1296 H1260 H1262
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
GO:0016740 transferase activity
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006139 nucleobase-containing compound metabolic process
GO:0006370 7-methylguanosine mRNA capping
GO:0019083 viral transcription
GO:0032259 methylation
GO:0039689 negative stranded viral RNA replication
GO:0106005 RNA 5'-cap (guanine-N7)-methylation
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5a22, PDBe:5a22, PDBj:5a22
PDBsum5a22
PubMed26144317
UniProtP03523|L_VSIVA RNA-directed RNA polymerase L (Gene Name=L)

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