Structure of PDB 5a1l Chain A

Receptor sequence
>5a1lA (length=443) Species: 9606 (Homo sapiens) [Search protein sequence]
KDKLNPPTPSIYLENKRDAFFPPLHQFCTNPKNPVTVIRGLAGALKLDLG
LFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWRCESNRSHTTI
AKYAQYQASSFQESLREENEKGPFKTIKFGTNIDLSDNKKWKLQLHELTK
LPAFARVVSAGNLLTHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSV
NINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYEANV
PVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAVER
YEWNKLKSVKSPVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQYQT
LREALVAAGKEVIWHGRTNDEPAHYCSICEVEVFNLLFVTNESNTQKTYI
VHCHDCARKTSKSLENFVVLEQYKMEDLIQVYDQFTLALSLSS
3D structure
PDB5a1l Crystal Structure of Jmjc Domain of Human Histone Demethylase Uty with S21056A
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.68: [histone H3]-trimethyl-L-lysine(27) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE2 A H1014 E1016 H191 E193
BS02 S2I A R869 Q871 F952 T954 Y1003 K1005 T1011 P1012 H1014 E1016 N1017 N1024 R69 Q71 F129 T131 Y180 K182 T188 P189 H191 E193 N194 N201
BS03 ZN A C1199 C1202 C1226 C1229 C376 C379 C403 C406
External links
PDB RCSB:5a1l, PDBe:5a1l, PDBj:5a1l
PDBsum5a1l
PubMed
UniProtO14607|UTY_HUMAN Histone demethylase UTY (Gene Name=UTY)

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