Structure of PDB 5a1f Chain A

Receptor sequence
>5a1fA (length=450) Species: 9606 (Homo sapiens) [Search protein sequence]
SMFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPP
FACDVDKLHFTPRIQRLNELEAQTRVRDYTLRTFGEMADAFKSDYFNMPV
HMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDSPEEEE
YLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDH
WSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLV
TIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFC
TVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQK
DMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSA
ISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAE
3D structure
PDB5a1f Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G481 Y488 H499 E501 H587 A599
Catalytic site (residue number reindexed from 1) G178 Y185 H196 E198 H284 A296
Enzyme Commision number 1.14.11.67: [histone H3]-trimethyl-L-lysine(4) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C692 C695 C715 H718 C389 C392 C412 H415
BS02 ZN A C706 C708 C723 C725 C403 C405 C420 C422
BS03 MN A L90 N91 L413 T416 E419 L67 N68 L115 T118 E121
BS04 MN A H499 E501 H587 H196 E198 H284
External links
PDB RCSB:5a1f, PDBe:5a1f, PDBj:5a1f
PDBsum5a1f
PubMed27214403
UniProtQ9UGL1|KDM5B_HUMAN Lysine-specific demethylase 5B (Gene Name=KDM5B)

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