Structure of PDB 4zzi Chain A

Receptor sequence
>4zziA (length=335) Species: 9606 (Homo sapiens) [Search protein sequence]
GPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPP
KRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYAR
LAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIAL
SDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEA
VRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDE
VDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDC
DVIINELCHRLGGEYAKLCCQYLFLPPNRYIFHGA
3D structure
PDB4zzi Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.
ChainA
Resolution2.7346 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P271 D272 F273 R274 N346 D348 H363
Catalytic site (residue number reindexed from 1) P89 D90 F91 R92 N164 D166 H181
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4TQ A P211 P212 I223 N226 P29 P30 I41 N44
BS02 1NS A A262 D272 F273 F297 N346 I347 D348 V412 F414 A80 D90 F91 F115 N164 I165 D166 V230 F232 BindingDB: IC50=4.3nM
BS03 ZN A C371 C374 C395 C398 C189 C192 C213 C216
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:4zzi, PDBe:4zzi, PDBj:4zzi
PDBsum4zzi
PubMed26134520
UniProtQ96EB6|SIR1_HUMAN NAD-dependent protein deacetylase sirtuin-1 (Gene Name=SIRT1)

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