Structure of PDB 4zy4 Chain A

Receptor sequence
>4zy4A (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
SDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAI
KQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT
DVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRNIKSDNILLGMDGSV
KLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIM
AIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLE
MDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEAT
3D structure
PDB4zy4 Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N389 K391 D393 N394 D407 P416 T427
Catalytic site (residue number reindexed from 1) N136 K138 D140 N141 D154 P163 T174
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4T3 A A297 E345 Y346 L347 A348 G350 L396 A49 E92 Y93 L94 A95 G97 L143 PDBbind-CN: -logKd/Ki=7.66,Ki=22nM
BindingDB: Ki=22nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4zy4, PDBe:4zy4, PDBj:4zy4
PDBsum4zy4
PubMed26030457
UniProtQ13153|PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (Gene Name=PAK1)

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