Structure of PDB 4zxh Chain A

Receptor sequence

>4zxhA (length=1314) Species: 557600 (Acinetobacter baumannii AB307-0294)

GHMNNLARLEPEVLSRHAISSEQLGIWYIQRLEPTCSAYNMVVAFDVKVN
QSLGNKPIEILEAVMHDYPLLRVSMPANDQGIEQLIWDRVYPNIIFSDAR
HIEASDLTQLVEQDTKQPFDLTQPPLWRIHCYECGQNHYVIAFVIHHALM
DFWSIGLLLRDVSKRFGLVAESDAVNGIEFVQYADKQQSSVIDDTDESLI
FWKNALKHAPHVHSIPLDYPRPAVQQHKGSSLVFRVSESVSSGLVNLAKD
YEITLFGLVLSGFYVLLHKLSNENNLVIATPVAGRLERSLRNALGQFVNT
IAIHMDIDADQTLRQFTQQVQEQLRQSLKHQKIAFSRVVEAVSPKRDGSI
NPLAQIGMFWERLGGMDEFKELLLPIQTPATLVGQDLTLGSFPVRQQEGQ
LDITLEMGGEYQGELVGVLKYNTDLFSAQSAENMVQLLQAVLSEMVAHPE
RKIVELDIAPDYKDGIQFEALRGKATDYAQHDLFAMILKQIDERGDNHAL
TSHTVSYRELGQHIAGIAEYLRAHGITQGDRVGLMLDRTALLPAAILGIW
AAGAAYVPLDPNFPTERLQNIIEDAEPKVILTQTELMDGLNVSVPRLDIN
QAGVVALEQVRETLAFGDIAYVMYTSKPKGVRIGHPSIINFLLSMNDRLQ
VTTETQLLAITTYAFDISILELLIPLMYGGVVHVCPREVSQDGIQLVDYL
NAKSINVLQATPATWKMLLDSEWSGNAGLTALCGGEALDTILAEKLLGKV
GCLWNVYGPTETTVWSSAARITDAKYIDLGEPLANTQLYVLDEQQRLVPP
GVMGELWIGGDGLAVDYWQRPELTDAQFRTLPSLPNAGRLYRTGDKVCLR
TDGRLTHHGRLDFQVKIRGFRIELGEIENVLKQIDGITDAVVLVKTTGDN
DQKLVAYVTGQELDIAGLKKNLQIHLPAYMVPSAFIRLDEFPMTANKKLD
RKAFPEPIFEQSNDYVAPRDPIEIELCTTFEQILSVKRVGIHDDFFELGG
HSLLAVKLVNHLKKAFGTELSVALLAQYSTVERLGEIIRENKEIKPSIVI
ELRRGTYEQPLWLFHPIGGSTFCYMELSRHLNPNRTLRAIQSPGLIEADA
AEVAIEEMATLYIAEMQKMQPQGPYFLGGWCFGGAIAYEISRQLRQMGQQ
VTGIVMIDTRAPIPENVPEDADDAMLLSWFARDLAAPYGKKLTIPAQYLR
ELSPDQMFDHVLKEAKAINVLPLDADPSDFRLYFDTYLANGIALQTYFPE
PEDFPILLVKAKDEQEDFGESLGWDQLVKDTLTQVDLPGDHSSIMYAENV
VAVAQTIDQMYPIP

3D structure

• PDB: 4zxh Structures of two distinct conformations of holo-non-ribosomal peptide synthetases.
• Chain: A
• Resolution: 2.7 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): T625 V754 V869 F874
• Catalytic site (residue number reindexed from 1): T625 V750 V865 F870

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PNS	A	G23 Y37 F333 R344 N349 F357 H1005 S1006	G25 Y39 F335 R346 N351 F359 H1001 S1002

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003824 catalytic activity
• GO:0031177 phosphopantetheine binding

Biological Process

• GO:0009058 biosynthetic process
• GO:0043041 amino acid activation for nonribosomal peptide biosynthetic process
• GO:0044550 secondary metabolite biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4zxh, PDBe:4zxh, PDBj:4zxh
• PDBsum: 4zxh
• PubMed: 26762461
• UniProt: A0A0X1KH98