Structure of PDB 4zwc Chain A

Receptor sequence
>4zwcA (length=468) Species: 9606 (Homo sapiens) [Search protein sequence]
TQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFITKTLTDKGNA
PPSEVLLTSLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAV
TGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRG
AFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSAAL
PFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMSQE
KQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQ
EPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVS
LLLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAM
AVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKVPE
TRGRTFEDITRAFEGQAH
3D structure
PDB4zwc Molecular basis of ligand recognition and transport by glucose transporters
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A Q159 I162 Q280 Q281 F377 W386 Q157 I160 Q278 Q279 F375 W384
BS02 GLC A F289 N413 F287 N411
Gene Ontology
Molecular Function
GO:0005353 fructose transmembrane transporter activity
GO:0005354 galactose transmembrane transporter activity
GO:0005515 protein binding
GO:0005536 D-glucose binding
GO:0022857 transmembrane transporter activity
GO:0033300 dehydroascorbic acid transmembrane transporter activity
GO:0055056 D-glucose transmembrane transporter activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0015755 fructose transmembrane transport
GO:0015757 galactose transmembrane transport
GO:0019852 L-ascorbic acid metabolic process
GO:0046323 D-glucose import
GO:0055085 transmembrane transport
GO:0070837 dehydroascorbic acid transport
GO:0098708 D-glucose import across plasma membrane
GO:0150104 transport across blood-brain barrier
GO:1904659 D-glucose transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016235 aggresome
GO:0030667 secretory granule membrane
GO:0035579 specific granule membrane
GO:0042995 cell projection
GO:0043204 perikaryon
GO:0070062 extracellular exosome
GO:0070821 tertiary granule membrane
GO:0101003 ficolin-1-rich granule membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zwc, PDBe:4zwc, PDBj:4zwc
PDBsum4zwc
PubMed26176916
UniProtP11169|GTR3_HUMAN Solute carrier family 2, facilitated glucose transporter member 3 (Gene Name=SLC2A3)

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