Structure of PDB 4zw9 Chain A

Receptor sequence
>4zw9A (length=470) Species: 9606 (Homo sapiens) [Search protein sequence]
MGTQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFITKTLTDKG
NAPPSEVLLTSLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLL
AVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTAL
RGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSA
ALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMS
QEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAG
VQEPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMT
VSLLLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPA
AMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKV
PETRGRTFEDITRAFEGQAH
3D structure
PDB4zw9 Molecular basis of ligand recognition and transport by glucose transporters
ChainA
Resolution1.502 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 GLC A Q159 I162 I166 Q280 Q281 N286 W386 Q159 I162 I166 Q280 Q281 N286 W386
BS02 BGC A Q159 I166 Q280 Q281 N286 F377 W386 Q159 I166 Q280 Q281 N286 F377 W386
Gene Ontology
Molecular Function
GO:0005353 fructose transmembrane transporter activity
GO:0005354 galactose transmembrane transporter activity
GO:0005515 protein binding
GO:0005536 D-glucose binding
GO:0022857 transmembrane transporter activity
GO:0033300 dehydroascorbic acid transmembrane transporter activity
GO:0055056 D-glucose transmembrane transporter activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0015755 fructose transmembrane transport
GO:0015757 galactose transmembrane transport
GO:0019852 L-ascorbic acid metabolic process
GO:0046323 D-glucose import
GO:0055085 transmembrane transport
GO:0070837 dehydroascorbic acid transport
GO:0098708 D-glucose import across plasma membrane
GO:0150104 transport across blood-brain barrier
GO:1904659 D-glucose transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016235 aggresome
GO:0030667 secretory granule membrane
GO:0035579 specific granule membrane
GO:0042995 cell projection
GO:0043204 perikaryon
GO:0070062 extracellular exosome
GO:0070821 tertiary granule membrane
GO:0101003 ficolin-1-rich granule membrane

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:4zw9, PDBe:4zw9, PDBj:4zw9
PDBsum4zw9
PubMed26176916
UniProtP11169|GTR3_HUMAN Solute carrier family 2, facilitated glucose transporter member 3 (Gene Name=SLC2A3)

[Back to BioLiP]