Structure of PDB 4zvi Chain A

Receptor sequence
>4zviA (length=357) Species: 562 (Escherichia coli) [Search protein sequence]
LDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEIIVTIHA
DNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLVGVSVVNALSQKLELVI
QRGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTNVTEFEYE
ILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTP
IHPNIFYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGF
RAAMTRTLNAYMDKEGYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQ
TKDKLVSSEVKSAVEQQMNELLAEYLLENPTDAKIVVGKIIDAARAREAA
RRAREMT
3D structure
PDB4zvi N-Phenyl-4,5-dibromopyrrolamides and N-Phenylindolamides as ATP Competitive DNA Gyrase B Inhibitors: Design, Synthesis, and Evaluation.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4S4 A N46 E50 D73 R76 P79 V120 N31 E35 D58 R61 P64 V86 MOAD: Kd=0.47uM
PDBbind-CN: -logKd/Ki=6.33,Kd=0.47uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4zvi, PDBe:4zvi, PDBj:4zvi
PDBsum4zvi
PubMed26126187
UniProtP0AES7|GYRB_ECO57 DNA gyrase subunit B (Gene Name=gyrB)

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