Structure of PDB 4ztq Chain A

Receptor sequence
>4ztqA (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
QWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEH
QLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLS
KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFG
WSVGTLDYLPPEMIEGEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRI
SRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSS
3D structure
PDB4ztq Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D256 K258 E260 N261 D274 T292
Catalytic site (residue number reindexed from 1) D130 K132 E134 N135 D148 T155
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4RM A L139 G142 V147 K162 Q185 L210 E211 Y212 A213 L263 A273 D274 L13 G16 V21 K36 Q59 L84 E85 Y86 A87 L137 A147 D148 PDBbind-CN: -logKd/Ki=6.32,IC50=0.48uM
BindingDB: IC50=480nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000212 meiotic spindle organization
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007052 mitotic spindle organization
GO:0007098 centrosome cycle
GO:0007100 mitotic centrosome separation
GO:0051321 meiotic cell cycle

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4ztq, PDBe:4ztq, PDBj:4ztq
PDBsum4ztq
PubMed27391133
UniProtO14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA)

[Back to BioLiP]