Structure of PDB 4zsl Chain A

Receptor sequence
>4zslA (length=341) Species: 9606 (Homo sapiens) [Search protein sequence]
DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRE
LKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQ
PLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFG
MARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIF
GEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLP
PRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHD
PDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARRE
3D structure
PDB4zsl Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.
ChainA
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D182 K184 S186 N187 D200 T224
Catalytic site (residue number reindexed from 1) D130 K132 S134 N135 D148 T172
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4QZ A Y66 K84 I86 N95 R98 T99 E102 I117 Y14 K32 I34 N43 R46 T47 E50 I65 PDBbind-CN: -logKd/Ki=5.00,IC50>10uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4zsl, PDBe:4zsl, PDBj:4zsl
PDBsum4zsl
PubMed27139631
UniProtQ13164|MK07_HUMAN Mitogen-activated protein kinase 7 (Gene Name=MAPK7)

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