Structure of PDB 4zsj Chain A

Receptor sequence
>4zsjA (length=344) Species: 9606 (Homo sapiens) [Search protein sequence]
DVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRT
LRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIH
SSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIG
DFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVG
CIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQ
SLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAK
YHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARRE
3D structure
PDB4zsj Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.
ChainA
Resolution2.48 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D182 K184 S186 N187 D200 T224
Catalytic site (residue number reindexed from 1) D133 K135 S137 N138 D151 T175
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4R0 A Y66 R98 T99 E102 L137 Y17 R49 T50 E53 L88 MOAD: ic50=2.3uM
PDBbind-CN: -logKd/Ki=5.64,IC50=2.3uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4zsj, PDBe:4zsj, PDBj:4zsj
PDBsum4zsj
PubMed27139631
UniProtQ13164|MK07_HUMAN Mitogen-activated protein kinase 7 (Gene Name=MAPK7)

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