Structure of PDB 4zsh Chain A

Receptor sequence
>4zshA (length=213) Species: 9606 (Homo sapiens) [Search protein sequence]
DMPVERILEAELAVEPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLD
DQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAI
FDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREK
VYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDT
PIDTFLMEMLEAP
3D structure
PDB4zsh 9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V280 K284 V298 R302 T449 F450 E453 P458 V35 K39 V53 R57 T204 F205 E208 P213
BS02 4XW A I268 A271 A272 Q275 F313 R316 L326 A327 C432 I23 A26 A27 Q30 F68 R71 L81 A82 C187 MOAD: Kd=90nM
PDBbind-CN: -logKd/Ki=7.05,Kd=90nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zsh, PDBe:4zsh, PDBj:4zsh
PDBsum4zsh
PubMed26030625
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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