Structure of PDB 4zsg Chain A

Receptor sequence
>4zsgA (length=347) Species: 9606 (Homo sapiens) [Search protein sequence]
VTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNA
KRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQ
IIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCEL
KIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLW
SVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRA
YIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPF
LAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARRE
3D structure
PDB4zsg Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.
ChainA
Resolution1.79 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D182 K184 S186 N187 D200 T224
Catalytic site (residue number reindexed from 1) D136 K138 S140 N141 D154 T178
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4QX A Y66 I86 N95 R98 T99 E102 L103 I117 Y20 I40 N49 R52 T53 E56 L57 I71 PDBbind-CN: -logKd/Ki=5.00,IC50>10uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4zsg, PDBe:4zsg, PDBj:4zsg
PDBsum4zsg
PubMed27139631
UniProtQ13164|MK07_HUMAN Mitogen-activated protein kinase 7 (Gene Name=MAPK7)

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