Structure of PDB 4zs4 Chain A

Receptor sequence
>4zs4A (length=253) Species: 44689 (Dictyostelium discoideum) [Search protein sequence]
ISSETGEMGILWEFDPIINKWIRLSMKLKVERKPFAEGALREAYHTVSLG
VGTDENYPLGTTKLFPPIEMISPISKNNEAMTQLKNGTKFVLKLYKKEQQ
ASRELYFEDVKMQMVCRDWGNKFNQKKPPKKIEFLMSWVVELIDRSPSSN
GQPILCSIEPLLVGEFKKNNSNYGAVLTNRSTPQAFSHFTYELSNKQMIV
VAIQGVDDLYTDPQIHTPDGKGFGLGNLGKAGINKFITTHKCNAVCALLD
LDV
3D structure
PDB4zs4 Characterization of the Catalytic and Nucleotide Binding Properties of the alpha-Kinase Domain of Dictyostelium Myosin-II Heavy Chain Kinase A.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.7: [myosin heavy-chain] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H742 H794 C796 C800 H188 H240 C242 C246
BS02 ATP A F586 G589 L591 R592 K645 E713 L716 F720 K722 D766 F35 G38 L40 R41 K93 E159 L162 F166 K168 D212 MOAD: Kd=20uM
Gene Ontology
Molecular Function
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4zs4, PDBe:4zs4, PDBj:4zs4
PDBsum4zs4
PubMed26260792
UniProtP42527|MHCKA_DICDI Myosin heavy chain kinase A (Gene Name=mhkA)

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