Structure of PDB 4zrn Chain A

Receptor sequence

>4zrnA (length=309) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]

MNILVTGGAGFIGSHVVDKLIENGYGVIVVDNLSSGKVENLNRNALFYEQ
SIEDEEMMERIFSLHRPEYVFHLAAQASVAISVREPARDAKTNIIGSLVL
LEKSIKYGVKKFIFSSTGGAIYGENVKVFPTPETEIPHPISPYGIAKYST
EMYLEFFAREYGLKYTVLRYANVYGPRQDPYGEAGVVAIFTERMLRGEEV
HIFGDGEYVRDYVYVDDVVRANLLAMEKGDNEVFNIGTGRGTTVNQLFKL
LKEITGYDKEPVYKPPRKGDVRKSILDYTKAKEKLGWEPKVSLEEGLKLT
VEYFRKTLE

3D structure

PDB

4zrn The structural basis of substrate promiscuity in UDP-hexose 4-epimerase from the hyperthermophilic Eubacterium Thermotoga maritima

Chain

Resolution

2.0 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	T117 G119 A120 Y143 K147 Y181 G185
Catalytic site (residue number reindexed from 1)	T117 G119 A120 Y143 K147 Y181 G185
Enzyme Commision number	5.1.3.2: UDP-glucose 4-epimerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	A	G7 G10 F11 I12 D31 N32 S34 S35 G36 S51 I52 L73 A74 A75 T92 S115 S116 Y143 K147 Y170 V173	G7 G10 F11 I12 D31 N32 S34 S35 G36 S51 I52 L73 A74 A75 T92 S115 S116 Y143 K147 Y170 V173
BS02	UPG	A	T117 G119 A120 Y143 N172 G185 V186 H201 F203 Y208 R210 V244 R267 D270	T117 G119 A120 Y143 N172 G185 V186 H201 F203 Y208 R210 V244 R267 D270

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding

View graph for
Molecular Function

External links

PDB	RCSB:4zrn, PDBe:4zrn, PDBj:4zrn
PDBsum	4zrn
PubMed	26344854
UniProt	Q9WYX9

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