Structure of PDB 4zqp Chain A

Receptor sequence
>4zqpA (length=354) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
DPVPTGGDDPHKVAMLGLTFDDVLLLPAASDVVPATADTSSQLTKKIRLK
VPLVSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVEMVKRSGG
LLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLKSE
VGDRVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSICTTRVVAGVGAP
QITAILEAVAACRPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAG
TAEAPGELIFVNGKQYKSYRGMGSLGAMRKLVPEGIEGRVPFRGPLSSVI
HQLTGGLRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDVAMTVEAP
NYYA
3D structure
PDB4zqp Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMP A S83 M85 G338 S339 I340 C341 D374 G397 S398 Y421 G423 M424 G425 E458 S56 M58 G186 S187 I188 C189 D222 G245 S246 Y269 G271 M272 G273 E284
BS02 KP3 A R108 T284 A285 H286 N289 V292 G334 G336 T343 M424 R81 T132 A133 H134 N137 V140 G182 G184 T191 M272 MOAD: Ki=1580nM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4zqp, PDBe:4zqp, PDBj:4zqp
PDBsum4zqp
PubMed26440283
UniProtP9WKI7|IMDH_MYCTU Inosine-5'-monophosphate dehydrogenase (Gene Name=guaB)

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